产品
编 号：F249973
分子式：C16H10ClF3N2O3
分子量：370.71
分子式：C16H10ClF3N2O3
分子量：370.71
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 202821-81-6
产品详情
生物活性：
BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.
体内研究：
BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo.Animal Model:Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.))
Dosage:10-100 μg/kg
Administration:Intravenous injection; 10-100 μg/kg; once
Result:Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.
体外研究：
BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells.
BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.
体内研究：
BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo.Animal Model:Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.))
Dosage:10-100 μg/kg
Administration:Intravenous injection; 10-100 μg/kg; once
Result:Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.
体外研究：
BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells.
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