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编 号:F249813
分子式:C42H68O12
分子量:764.98
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生物活性:
Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain.

体外研究:
Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively.Dinactin (0-100 μM) shows antitumor activity with IC50 values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 μM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively.Dinactin (0.5, 1, 2 μM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells.inactin (0.5, 1, 2 μM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells.
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