产品
编 号：F028321
分子式：C102H172N36O32S7
分子量：2639.13
分子式：C102H172N36O32S7
分子量：2639.13
产品类型
规格
价格
是否有货
结构图
CAS No: 107452-89-1
产品详情
生物活性：
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.
体内研究：
Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE).Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein
Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
体外研究：
Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes.Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission.
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.
体内研究：
Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE).Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein
Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
体外研究：
Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes.Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备