产品
编 号:F249092
分子式:C36H56O12
分子量:680.82
产品类型
结构图
CAS No: 20183-47-5
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产品详情
生物活性:
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).
体内研究:
Tenuifolin(20-80 mg/kg;口服;单剂量)对 APP/PS1 小鼠的学习和记忆产生有益影响,防止神经元丢失和凋亡。
体外研究:
Tenuifolin (50 μM; 24 h) 保护 SH-SY5Y 细胞免受 Aβ25-35 (20 μM) 诱导的细胞凋亡,并降低 caspase-3 和 -9 的 mRNA 水平。Tenuifolin (50 μM,100 μM;24 h) 抑制 Aβ25-35 (20 μM) 诱导的 SH-SY5Y 细胞线粒体膜电位丧失。