产品
编 号：F248568
分子式：C25H25F2N5O2
分子量：465.5
分子式：C25H25F2N5O2
分子量：465.5
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CAS No: 2011034-33-4
产品详情
生物活性：
VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia.
体内研究：
VU6004256 (10 mg/kg; i.p.) 减弱 NR1 KD 小鼠前额皮质中过度的锥体细胞放电。VU6004256 (3, 10 mg/kg; i.p.) 逆转 NR1 KD 小鼠新物体识别和提示介导的恐惧条件反射任务中的表现障碍并减少过度运动活动。Animal Model:Adult male NR1 KD mice
Dosage:10 mg/kg
Administration:I.p.
Result:Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
Animal Model:Wild-type and NR1 KD mice
Dosage:3, 10 mg/kg
Administration:I.p.
Result:Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia.
体内研究：
VU6004256 (10 mg/kg; i.p.) 减弱 NR1 KD 小鼠前额皮质中过度的锥体细胞放电。VU6004256 (3, 10 mg/kg; i.p.) 逆转 NR1 KD 小鼠新物体识别和提示介导的恐惧条件反射任务中的表现障碍并减少过度运动活动。Animal Model:Adult male NR1 KD mice
Dosage:10 mg/kg
Administration:I.p.
Result:Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
Animal Model:Wild-type and NR1 KD mice
Dosage:3, 10 mg/kg
Administration:I.p.
Result:Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
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