产品
编 号：F248532
分子式：C18H28N2O3S
分子量：352.49
分子式：C18H28N2O3S
分子量：352.49
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CAS No: 201038-74-6
产品详情
生物活性：
SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors.
体内研究：
SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity.Animal Model:Male C57BL6/J mice
Dosage:3, 10, 30 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly blocked amphetamine and ketamine-induced hyperactivity.
SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors.
体内研究：
SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity.Animal Model:Male C57BL6/J mice
Dosage:3, 10, 30 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly blocked amphetamine and ketamine-induced hyperactivity.
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