产品
编 号:F248420
分子式:C7H9N5S
分子量:195.24
产品类型
结构图
CAS No: 200933-27-3
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产品详情
生物活性:
(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis.
体外研究:
3-AP shows anti-proliferative activity with IC50 values of 1.3, 1.6 μM for L1210, L1210/HUr cells, respectively.3-AP (5, 10, 15, 20, 30 mg/kg; i.p.; twice daily for six consecutive days) significantly increases in life span were observed with each dosage employed and long term survivors.