产品
编 号：F248319
分子式：C23H30N2O10
分子量：494.49
分子式：C23H30N2O10
分子量：494.49
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CAS No: 200815-49-2
产品详情
生物活性：
Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD).
体内研究：
Arformoterol tartrate (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) mitigates Cl2-induced increases of respiratory system resistance and elastance in mice.Arformoterol tartrate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively).Animal Model:Wild-type and iNOS?/? mice were exposed to Cl2 gas
Dosage:10 ng in 0.1 ml saline/20 g body weight
Administration:Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
Result:Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.Increased cAMP in the lungs of Cl2-exposed mice.Not mitigated Cl2-induced lung injury and inflammation.
体外研究：
Arformoterol tartrate induces cAMP accumulation in cultured human bronchial epithelial cells.
Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD).
体内研究：
Arformoterol tartrate (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) mitigates Cl2-induced increases of respiratory system resistance and elastance in mice.Arformoterol tartrate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively).Animal Model:Wild-type and iNOS?/? mice were exposed to Cl2 gas
Dosage:10 ng in 0.1 ml saline/20 g body weight
Administration:Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
Result:Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.Increased cAMP in the lungs of Cl2-exposed mice.Not mitigated Cl2-induced lung injury and inflammation.
体外研究：
Arformoterol tartrate induces cAMP accumulation in cultured human bronchial epithelial cells.
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