产品
编 号：F247497
分子式：C16H18BrNO2
分子量：336.22
分子式：C16H18BrNO2
分子量：336.22
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CAS No: 20012-10-6
产品详情
生物活性：
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.
体内研究：
SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione.SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine.SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline.SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action.Animal Model:Balb/c mice (20-25 g)
Dosage:5 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
体外研究：
SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP.SKF-38393 hydrochloride (10 μM; 1 hour)induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.
体内研究：
SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione.SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine.SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline.SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action.Animal Model:Balb/c mice (20-25 g)
Dosage:5 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
体外研究：
SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP.SKF-38393 hydrochloride (10 μM; 1 hour)induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
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