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编 号：F247435
分子式：C22H16O6
分子量：376.36
分子式：C22H16O6
分子量：376.36
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CAS No: 20004-62-0
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生物活性：
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.
体外研究：
Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation.Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance.Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells.Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo.
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.
体外研究：
Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation.Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance.Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells.Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo.
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