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编 号:F028137
分子式:C18H20Cl2N2O3
分子量:383.27
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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生物活性:
WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections.

体内研究:
WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively.

体外研究:
WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL).WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/mL.
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