产品
编 号：F247281
分子式：C14H24N4O4
分子量：312.36
分子式：C14H24N4O4
分子量：312.36
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1998725-11-3
产品详情
生物活性：
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
体内研究：
JHU-083 (1.82 mg/kg；口服；每隔一天一次，持续 12 天) 改善由 CSDS 诱导的社交回避行为和快感缺乏样行为。 JHU-083 (1.82 mg/kg；口服) 减弱 CSDS 诱导的前额皮质和海马 CD11b+ 细胞中谷氨酰胺酶活性的增加，但不影响小脑。JHU-083 处理可抑制 CSDS 诱导的 IL-1β 和 TNF-α 表达上调。Animal Model:Male 7-to 8-week-old C57BL/6J (C57) mice (25-30?g) with chronic social defeat stress (CSDS)
Dosage:1.82?mg/kg
Administration:PO; every other day for 12 days
Result:Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
体内研究：
JHU-083 (1.82 mg/kg；口服；每隔一天一次，持续 12 天) 改善由 CSDS 诱导的社交回避行为和快感缺乏样行为。 JHU-083 (1.82 mg/kg；口服) 减弱 CSDS 诱导的前额皮质和海马 CD11b+ 细胞中谷氨酰胺酶活性的增加，但不影响小脑。JHU-083 处理可抑制 CSDS 诱导的 IL-1β 和 TNF-α 表达上调。Animal Model:Male 7-to 8-week-old C57BL/6J (C57) mice (25-30?g) with chronic social defeat stress (CSDS)
Dosage:1.82?mg/kg
Administration:PO; every other day for 12 days
Result:Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
产品资料
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