产品
编 号：F246725
分子式：C24H30Cl2O6
分子量：485.4
分子式：C24H30Cl2O6
分子量：485.4
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CAS No: 199331-40-3
产品详情
生物活性：
Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.
体内研究：
Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats.Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration).Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs.Animal Model:Allergen sensitized and challenged Brown Norway rats
Dosage:0.1, 1, 10, and 100 μg/kg
Administration:Intranasal inhalation
Result:Decreased the number of eosinophils at the perivascular area of the lung tissue.Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.
体外研究：
Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood.
Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.
体内研究：
Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats.Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration).Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs.Animal Model:Allergen sensitized and challenged Brown Norway rats
Dosage:0.1, 1, 10, and 100 μg/kg
Administration:Intranasal inhalation
Result:Decreased the number of eosinophils at the perivascular area of the lung tissue.Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.
体外研究：
Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood.
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