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编 号：F246575
分子式：C22H31ClN4O7S2
分子量：563.09
分子式：C22H31ClN4O7S2
分子量：563.09
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CAS No: 199191-69-0
产品详情
生物活性：
Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).
体内研究：
Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold.Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
体外研究：
Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current.
Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).
体内研究：
Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold.Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
体外研究：
Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current.
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