产品
编 号：F246245
分子式：C21H22O4
分子量：338.4
分子式：C21H22O4
分子量：338.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 19879-30-2
产品详情
生物活性：
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity..
体内研究：
Bavachinin (5 mg/kg；腹腔注射；连续四周) 可抑制携带 KB 肿瘤的裸鼠肿瘤生长和血管生成。Bavachinin (50 mg/kg；口服；连续七天) 对哮喘小鼠有治疗作用。Animal Model:Athymic nude mice inoculated subcutaneously KB cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed significantly reduced the tumor volume by 40.06%, and had fewer vessels of luminal size.
Animal Model:Asthma mice
Dosage:50 mg/kg
Administration:Oral gavage (p.o.)
Result:Showed significantly inhibiting the serum levels of both IL-4 and IgE.
体外研究：
Bavachinin (25，50 μM；24 h) 提高 PPARγ 蛋白表达。
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity..
体内研究：
Bavachinin (5 mg/kg；腹腔注射；连续四周) 可抑制携带 KB 肿瘤的裸鼠肿瘤生长和血管生成。Bavachinin (50 mg/kg；口服；连续七天) 对哮喘小鼠有治疗作用。Animal Model:Athymic nude mice inoculated subcutaneously KB cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed significantly reduced the tumor volume by 40.06%, and had fewer vessels of luminal size.
Animal Model:Asthma mice
Dosage:50 mg/kg
Administration:Oral gavage (p.o.)
Result:Showed significantly inhibiting the serum levels of both IL-4 and IgE.
体外研究：
Bavachinin (25，50 μM；24 h) 提高 PPARγ 蛋白表达。
产品资料
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