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编 号：F245747
分子式：C18H20N2S
分子量：296.43
分子式：C18H20N2S
分子量：296.43
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CAS No: 1982-37-2
产品详情
生物活性：
Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.
体内研究：
Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice.Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice.Animal Model:H37Rv infected mice
Dosage:10 μg/gm body wt/day, 6 weeks
Administration:Intraperitoneal injection
Result:Displayed an anti-mycobacterial activity to mycobacteria.
Animal Model:Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice
Dosage:10 mg/kg per day for 28 days
Administration:Oral administration
Result:Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
体外研究：
Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.
体内研究：
Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice.Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice.Animal Model:H37Rv infected mice
Dosage:10 μg/gm body wt/day, 6 weeks
Administration:Intraperitoneal injection
Result:Displayed an anti-mycobacterial activity to mycobacteria.
Animal Model:Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice
Dosage:10 mg/kg per day for 28 days
Administration:Oral administration
Result:Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
体外研究：
Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
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