产品
编 号：F245164
分子式：C16H10F3N5
分子量：329.28
分子式：C16H10F3N5
分子量：329.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1976050-09-5
产品详情
生物活性：
Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease.
体内研究：
Valiglurax (VU0652957; 0.3-30 mg/kg; po) 以剂量依赖性方式逆转 haloperidol (HY-14538) 诱导的大鼠僵直症 (HIC)。Animal Model:haloperidol-induced catalepsy (HIC) in rats
Dosage:0.3-30 mg/kg
Administration:Oral administration
Result:Reversed haloperidol (HY-14538)-induced catalepsy (HIC) in rats in a dose-dependent manner.
Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease.
体内研究：
Valiglurax (VU0652957; 0.3-30 mg/kg; po) 以剂量依赖性方式逆转 haloperidol (HY-14538) 诱导的大鼠僵直症 (HIC)。Animal Model:haloperidol-induced catalepsy (HIC) in rats
Dosage:0.3-30 mg/kg
Administration:Oral administration
Result:Reversed haloperidol (HY-14538)-induced catalepsy (HIC) in rats in a dose-dependent manner.
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