产品
编 号：F244579
分子式：C18H16ClN3O2
分子量：341.79
分子式：C18H16ClN3O2
分子量：341.79
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
204
In-stock
5mg
508
In-stock
10mg
867
In-stock
50mg
2772
In-stock
结构图
CAS No: 196868-63-0
产品详情
生物活性：
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.
体内研究：
PQ401 (50 or 100 mg/kg; i.p.; thrice a week) results in a significant dose-dependent reduction in tumor growth over the course of the study. PQ401 reduces the growth rate of MCNeuA cells implanted into mice.Animal Model:Female mice were MCNeuA tumor cells
Dosage:50 or 100 mg/kg
Administration:Administered i.p. thrice a week; 24 days
Result:Resulted in a significant dose-dependent reduction in tumor growth. Tumor growth in the animals treated with 100 mg/kg was 20% of that in the vehicle-treated controls. This dosing protocol was well tolerated by the animals.
体外研究：
PQ401 (1, 5, 10, 25, and 50 μM; 3 days) inhibits proliferation of cultured MCF-7 cells grown in serum or IGF-I in MCF-7 cells.Twenty-four hours of treatment with 15 μM PQ401 induces caspase-mediated apoptosis. PQ401 inhibits autophosphorylation of the IGF-IR kinase domain at concentrations PQ401 相关抗体:Cell Proliferation AssayCell Line:Breast cancer cells, MCF-7 cells
Concentration:1, 5, 10, 25, and 50 μM
Incubation Time:3 days
Result:Significantly reduced proliferation (IC50, 8 μM) at concentrations in the range of 1 μM.Produced a dramatic reduction in cell number from pretreatment levels at concentrations >10 μM.
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.
体内研究：
PQ401 (50 or 100 mg/kg; i.p.; thrice a week) results in a significant dose-dependent reduction in tumor growth over the course of the study. PQ401 reduces the growth rate of MCNeuA cells implanted into mice.Animal Model:Female mice were MCNeuA tumor cells
Dosage:50 or 100 mg/kg
Administration:Administered i.p. thrice a week; 24 days
Result:Resulted in a significant dose-dependent reduction in tumor growth. Tumor growth in the animals treated with 100 mg/kg was 20% of that in the vehicle-treated controls. This dosing protocol was well tolerated by the animals.
体外研究：
PQ401 (1, 5, 10, 25, and 50 μM; 3 days) inhibits proliferation of cultured MCF-7 cells grown in serum or IGF-I in MCF-7 cells.Twenty-four hours of treatment with 15 μM PQ401 induces caspase-mediated apoptosis. PQ401 inhibits autophosphorylation of the IGF-IR kinase domain at concentrations PQ401 相关抗体:Cell Proliferation AssayCell Line:Breast cancer cells, MCF-7 cells
Concentration:1, 5, 10, 25, and 50 μM
Incubation Time:3 days
Result:Significantly reduced proliferation (IC50, 8 μM) at concentrations in the range of 1 μM.Produced a dramatic reduction in cell number from pretreatment levels at concentrations >10 μM.
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