产品
编 号：F244437
分子式：C30H52O3
分子量：460.73
分子式：C30H52O3
分子量：460.73
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 19666-76-3
产品详情
生物活性：
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.
体内研究：
Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model.Animal Model:BALB/c athymic nude mice injected with HCT116 cells
Dosage:10 or 30 mg/kg
Administration:Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days
Result:Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.
体外研究：
Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells.Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells.
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.
体内研究：
Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model.Animal Model:BALB/c athymic nude mice injected with HCT116 cells
Dosage:10 or 30 mg/kg
Administration:Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days
Result:Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.
体外研究：
Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells.Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells.
产品资料
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