产品
编 号：F027376
分子式：C10H17NOS
分子量：199.31
分子式：C10H17NOS
分子量：199.31
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CAS No: 107233-08-9
产品详情
生物活性：
Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.
Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.
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