产品
编 号：F244121
分子式：C24H16BrFN4O2S
分子量：523.38
分子式：C24H16BrFN4O2S
分子量：523.38
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1962931-71-0
产品详情
生物活性：
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.
体外研究：
JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.
体外研究：
JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.
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