产品
编 号：F027338
分子式：C10H18ClNOS
分子量：235.77
分子式：C10H18ClNOS
分子量：235.77
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 107220-28-0
产品详情
生物活性：
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).
体内研究：
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II
Dosage:0.008 mg/kg, 0.016 mg/kg
Administration:Intraperitoneal injection
Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
体外研究：
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.
产品资料
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