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编 号：F243957
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CAS No: 195962-23-3
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生物活性：
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.
体内研究：
Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats.Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats.Corifollitropin alfa (3 μg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits.Animal Model:Rats
Dosage:2.5, 5, 10, 20, 40 μg/kg.
Administration:Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result:Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.
体内研究：
Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats.Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats.Corifollitropin alfa (3 μg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits.Animal Model:Rats
Dosage:2.5, 5, 10, 20, 40 μg/kg.
Administration:Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result:Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
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