产品
编 号：F243338
分子式：C19H23NO
分子量：281.39
分子式：C19H23NO
分子量：281.39
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 195615-83-9
产品详情
生物活性：
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.
体内研究：
Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration.Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice.Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response.Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice.Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice
Dosage:10 mg/kg, 30 mg/kg
Administration:Oral administration, daily, for 6.5 weeks
Result:Reverse the deficits observed in the HET animals.
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.
体内研究：
Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration.Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice.Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response.Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice.Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice
Dosage:10 mg/kg, 30 mg/kg
Administration:Oral administration, daily, for 6.5 weeks
Result:Reverse the deficits observed in the HET animals.
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