产品
编 号：F242387
分子式：C6H12O5
分子量：164.16
分子式：C6H12O5
分子量：164.16
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CAS No: 1949-89-9
产品详情
生物活性：
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo.
体内研究：
2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers.2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration.Animal Model:Male adult Wistar rats with passive avoidance response (PAR) acquisition trial
Dosage:2, 4 and 8 μM
Administration:Intracerebroventricularly injection; 2-8 μM; once
Result:Exhibited PAR disruption at a dose of 4 μM.
体外研究：
2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells.
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo.
体内研究：
2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers.2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration.Animal Model:Male adult Wistar rats with passive avoidance response (PAR) acquisition trial
Dosage:2, 4 and 8 μM
Administration:Intracerebroventricularly injection; 2-8 μM; once
Result:Exhibited PAR disruption at a dose of 4 μM.
体外研究：
2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells.
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