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编 号：F242006
分子式：C28H27ClO4S
分子量：495.03
分子式：C28H27ClO4S
分子量：495.03
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CAS No: 194608-80-5
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生物活性：
L-796449 is a potent PPARγ agonist. L-796449 shows neuroprotective. L-796449 has the potential for the research of stroke.
体内研究：
L-796449 (1 mg/kg；腹腔注射) 对大鼠大脑中大脑动脉闭塞 (MCAO) 具有神经保护作用。Animal Model:250 g adult male Fischer rats
Dosage:1 mg/kg (MCAO 10 minutes before IP injection)
Administration:I.p.
Result:Decreased MCAO-induced infarct size determined 2 and 7 days after the ischemic injury, inhibited MCAO-induced expression of iNOS and MMP-9 but did not affect COX-2 levels at the time examined; increased the expression of heme oxygenase-1 (HO-1) and inhibited NF-κB signaling.
L-796449 is a potent PPARγ agonist. L-796449 shows neuroprotective. L-796449 has the potential for the research of stroke.
体内研究：
L-796449 (1 mg/kg；腹腔注射) 对大鼠大脑中大脑动脉闭塞 (MCAO) 具有神经保护作用。Animal Model:250 g adult male Fischer rats
Dosage:1 mg/kg (MCAO 10 minutes before IP injection)
Administration:I.p.
Result:Decreased MCAO-induced infarct size determined 2 and 7 days after the ischemic injury, inhibited MCAO-induced expression of iNOS and MMP-9 but did not affect COX-2 levels at the time examined; increased the expression of heme oxygenase-1 (HO-1) and inhibited NF-κB signaling.
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