产品
编 号：F241876
分子式：C17H13BrN4O
分子量：369.22
分子式：C17H13BrN4O
分子量：369.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
440
In-stock
5mg
616
In-stock
10mg
1040
In-stock
25mg
2080
In-stock
50mg
3680
In-stock
结构图
CAS No: 194423-15-9
产品详情
生物活性：
PD168393?is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC.
体内研究：
PD168393 (intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28) is effective?in vivo, and produces tumor growth inhibition of 115% after 15 days’ treatment in human epidermoid carcinoma xenografts in mice.Animal Model:A431 human epidermoid carcinoma grown as a xenograft in nude mice
Dosage:58 mg/kg
Administration:Intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28
Result:Suppressed the growth of human epidermoid carcinoma xenografts.
体外研究：
PD168393 inhibits ligand-dependent receptor phosphorylation and?inhibits EGF-induced tyrosine phosphorylation in A431 cells and Heregulin-induced tyrosine phosphorylation in MDA-MB-453 cells with IC50 values of 4.3? nM and 5.7? nM, respectively.
PD168393?is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC.
体内研究：
PD168393 (intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28) is effective?in vivo, and produces tumor growth inhibition of 115% after 15 days’ treatment in human epidermoid carcinoma xenografts in mice.Animal Model:A431 human epidermoid carcinoma grown as a xenograft in nude mice
Dosage:58 mg/kg
Administration:Intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28
Result:Suppressed the growth of human epidermoid carcinoma xenografts.
体外研究：
PD168393 inhibits ligand-dependent receptor phosphorylation and?inhibits EGF-induced tyrosine phosphorylation in A431 cells and Heregulin-induced tyrosine phosphorylation in MDA-MB-453 cells with IC50 values of 4.3? nM and 5.7? nM, respectively.
产品资料
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