产品
编 号：F241848
分子式：C22H22ClN3O4S
分子量：459.95
分子式：C22H22ClN3O4S
分子量：459.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
890
In-stock
1mg
335
In-stock
5mg
880
In-stock
10mg
1520
In-stock
25mg
3120
In-stock
50mg
5520
In-stock
结构图
CAS No: 1943733-16-1
产品详情
生物活性：
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.
体内研究：
YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.
体外研究：
YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.
体内研究：
YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.
体外研究：
YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.
产品资料
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