产品
编 号：F241774
分子式：C21H30NO5P
分子量：407.44
分子式：C21H30NO5P
分子量：407.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 19428-14-9
产品详情
生物活性：
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.
体内研究：
Benproperine phosphate (50、100 mg/kg；口服强饲法；每周 5 天，持续 4 周) 抑制原发性胰腺肿瘤生长。 Benproperine phosphate 显著降低小鼠 AsPC-1 细胞的肺转移 (56.1% 抑制)。Benproperine phosphate 显著抑制 HCT-116 细胞和 DLD-1 细胞 78.9% 和 78.2% 的肝转移。Animal Model:Female BALB/c nude mice of 6-week-old with AsPC-1 cells
Dosage:50, 100?mg/kg
Administration:Oral gavage; 5?days per week for 4?weeks
Result:Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.
体外研究：
Benproperine phosphate (20-120 μM；持续 24 小时) 以剂量依赖性方式抑制细胞活力。 Benproperine phosphate (10 μM；作用24小时) 显著抑制各类癌细胞的迁移，抑制DLD-1、AsPC-1细胞的迁移和侵袭，IC50 值 1-2 μM。Benproperine phosphate（10 μM；作用 24 小时）不会影响 MCF-10A 细胞中富含皮质素的片状足。
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.
体内研究：
Benproperine phosphate (50、100 mg/kg；口服强饲法；每周 5 天，持续 4 周) 抑制原发性胰腺肿瘤生长。 Benproperine phosphate 显著降低小鼠 AsPC-1 细胞的肺转移 (56.1% 抑制)。Benproperine phosphate 显著抑制 HCT-116 细胞和 DLD-1 细胞 78.9% 和 78.2% 的肝转移。Animal Model:Female BALB/c nude mice of 6-week-old with AsPC-1 cells
Dosage:50, 100?mg/kg
Administration:Oral gavage; 5?days per week for 4?weeks
Result:Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.
体外研究：
Benproperine phosphate (20-120 μM；持续 24 小时) 以剂量依赖性方式抑制细胞活力。 Benproperine phosphate (10 μM；作用24小时) 显著抑制各类癌细胞的迁移，抑制DLD-1、AsPC-1细胞的迁移和侵袭，IC50 值 1-2 μM。Benproperine phosphate（10 μM；作用 24 小时）不会影响 MCF-10A 细胞中富含皮质素的片状足。
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