产品
编 号：F241531
分子式：C29H40O4
分子量：452.63
分子式：C29H40O4
分子量：452.63
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 193957-88-9
产品详情
生物活性：
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.
体内研究：
Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).Animal Model:Zebrafish
Dosage:0.5?μM, 1?μM and 1.25?μM
Administration:72 h
Result:Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25?μM for 24?h or at a concentration of 0.5?μM for 72?h.
体外研究：
Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin.
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.
体内研究：
Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).Animal Model:Zebrafish
Dosage:0.5?μM, 1?μM and 1.25?μM
Administration:72 h
Result:Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25?μM for 24?h or at a concentration of 0.5?μM for 72?h.
体外研究：
Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备