产品
编 号：F241377
分子式：C27H23FN6O
分子量：466.51
分子式：C27H23FN6O
分子量：466.51
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1937235-76-1
产品详情
生物活性：
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.
体内研究：
KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment.Animal Model:C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily; for 14 days
Result:Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased.
体外研究：
KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12.
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.
体内研究：
KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment.Animal Model:C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily; for 14 days
Result:Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased.
体外研究：
KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12.
产品资料
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