产品
编 号：F241373
分子式：CH7ClN4
分子量：110.55
分子式：CH7ClN4
分子量：110.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 1937-19-5
产品详情
生物活性：
Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research.
体内研究：
Aminoguanidine (50 mg/kg, 腹腔注射) 可保护小鼠免受 CCl4 诱导的肝毒性。Aminoguanidine (200 mg/kg, 单剂量腹腔注射) 在大鼠中对环磷酰胺 (CP) 诱导的氧化应激和肾损伤具有保护作用。Animal Model:Male Swiss albino mice
Dosage:50 mg/kg
Administration:Intraperitoneally 30 min before the administration of CCl4
Result:Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation.
Animal Model:Adult male Wistar rats
Dosage:200 mg/kg
Administration:Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection.
Result:Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation.Restored the GSH levels and attenuated CP-induced increase in MPO activity.
体外研究：
Aminoguanidine (100-1000 μM, 24 h) 在A549 细胞中可降低 DOX 诱导的 DNA 损伤和细胞凋亡。Aminoguanidine (100 μM, 30 min) 在 AR42J 细胞中可诱导 ERK 活化，促进细胞增殖。
Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research.
体内研究：
Aminoguanidine (50 mg/kg, 腹腔注射) 可保护小鼠免受 CCl4 诱导的肝毒性。Aminoguanidine (200 mg/kg, 单剂量腹腔注射) 在大鼠中对环磷酰胺 (CP) 诱导的氧化应激和肾损伤具有保护作用。Animal Model:Male Swiss albino mice
Dosage:50 mg/kg
Administration:Intraperitoneally 30 min before the administration of CCl4
Result:Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation.
Animal Model:Adult male Wistar rats
Dosage:200 mg/kg
Administration:Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection.
Result:Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation.Restored the GSH levels and attenuated CP-induced increase in MPO activity.
体外研究：
Aminoguanidine (100-1000 μM, 24 h) 在A549 细胞中可降低 DOX 诱导的 DNA 损伤和细胞凋亡。Aminoguanidine (100 μM, 30 min) 在 AR42J 细胞中可诱导 ERK 活化，促进细胞增殖。
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