产品
编 号：F241107
分子式：C28H31ClN4O4
分子量：523.02
分子式：C28H31ClN4O4
分子量：523.02
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 193611-67-5
产品详情
生物活性：
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.
体内研究：
SB-216641A (0.6-20 mg/kg；腹腔注射；单剂量) 在豚鼠内以剂量依赖性方式阻碍 SKF-99101H 诱导的低体温。SB-216641A (559 nmol/kg；静脉注射；单剂量) 与 5-HT1B/D 受体拮抗剂 GR-127935 联用时改善了狗注射 800 nmol/kg 舒马曲坦 Sumatriptan (HY-B0121B) 后观察到的胃松弛。Animal Model:Guinea pigs.
Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Significantly blocked the effects of SKF-99101H.
Animal Model:Dogs.
Dosage:559 nmol/kg.
Administration:Intravenous injection; single dose.
Result:Improved the gastric relaxation.
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.
体内研究：
SB-216641A (0.6-20 mg/kg；腹腔注射；单剂量) 在豚鼠内以剂量依赖性方式阻碍 SKF-99101H 诱导的低体温。SB-216641A (559 nmol/kg；静脉注射；单剂量) 与 5-HT1B/D 受体拮抗剂 GR-127935 联用时改善了狗注射 800 nmol/kg 舒马曲坦 Sumatriptan (HY-B0121B) 后观察到的胃松弛。Animal Model:Guinea pigs.
Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Significantly blocked the effects of SKF-99101H.
Animal Model:Dogs.
Dosage:559 nmol/kg.
Administration:Intravenous injection; single dose.
Result:Improved the gastric relaxation.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备