产品
编 号：F240880
分子式：C17H22IN3
分子量：395.28
分子式：C17H22IN3
分子量：395.28
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
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25mg
询价
询价
50mg
询价
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100mg
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结构图
CAS No: 193527-91-2
产品详情
生物活性：
IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. IPAG induces apoptosis.
体外研究：
Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells.IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass.IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1.
IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. IPAG induces apoptosis.
体外研究：
Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells.IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass.IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1.
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