产品
编 号：F239874
分子式：C24H28ClFN2O2
分子量：430.94
分子式：C24H28ClFN2O2
分子量：430.94
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
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询价
结构图
CAS No: 192927-92-7
产品详情
生物活性：
LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HT.
体内研究：
LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model.Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).
Dosage:10 mg/kg
Administration:Intraperitoneal injection; single
Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.
Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).
Dosage:1 mg/kg
Administration:Intravenous injection; single
Result:Completely abolished 5-HT vasodilator effects.
体外研究：
LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HT.
体内研究：
LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model.Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).
Dosage:10 mg/kg
Administration:Intraperitoneal injection; single
Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.
Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).
Dosage:1 mg/kg
Administration:Intravenous injection; single
Result:Completely abolished 5-HT vasodilator effects.
体外研究：
LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
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