产品
编 号：F239222
分子式：C24H30O11
分子量：494.49
分子式：C24H30O11
分子量：494.49
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
20mg
询价
询价
结构图
CAS No: 19210-12-9
产品详情
生物活性：
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).
体内研究：
Harpagoside (5 mg/kg; 15 mg/kg; 口服; 每天 1 次共 60 天) 在 Aβ1-40 诱导的大鼠阿尔茨海默病 (AD) 模型中，对 Aβ 中毒有潜在的神经保护作用。
体外研究：
Harpagoside (200 μM; 2 h+1 h, 6 h) 抑制 HepG2 细胞中脂多糖 (100 ng/mL LPS) 诱导的 mRNA 水平以及环氧合酶 2 和诱导型一氧化氮的蛋白表达。Harpagoside (0.1-200 μM; 4 h+1 h, 6 h) 呈剂量依赖性地抑制 LPS 刺激的 NF-κB 启动子活性，干扰基因转录的激活。
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).
体内研究：
Harpagoside (5 mg/kg; 15 mg/kg; 口服; 每天 1 次共 60 天) 在 Aβ1-40 诱导的大鼠阿尔茨海默病 (AD) 模型中，对 Aβ 中毒有潜在的神经保护作用。
体外研究：
Harpagoside (200 μM; 2 h+1 h, 6 h) 抑制 HepG2 细胞中脂多糖 (100 ng/mL LPS) 诱导的 mRNA 水平以及环氧合酶 2 和诱导型一氧化氮的蛋白表达。Harpagoside (0.1-200 μM; 4 h+1 h, 6 h) 呈剂量依赖性地抑制 LPS 刺激的 NF-κB 启动子活性，干扰基因转录的激活。
产品资料
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