产品
编 号：F237886
分子式：C15H22N4O2
分子量：290.36
分子式：C15H22N4O2
分子量：290.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 1905481-36-8
产品详情
生物活性：
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).
体内研究：
KDM5A-IN-1(化合物50,5 mg/kg;口服;雌性CD-1小鼠) 对小鼠的清除率中等 (28 mL/min/kg)，具有良好的口服生物利用度(F% 34)，小鼠血浆蛋白结合明显低(40%)，t1/2为0.4小时。Animal Model:Female CD-1 mice
Dosage:5 mg/kg
Administration:Oral administration (Pharmacokinetic study)
Result:Moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34), and showed remarkably low plasma protein binding in mice (40%).
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).
体内研究：
KDM5A-IN-1(化合物50,5 mg/kg;口服;雌性CD-1小鼠) 对小鼠的清除率中等 (28 mL/min/kg)，具有良好的口服生物利用度(F% 34)，小鼠血浆蛋白结合明显低(40%)，t1/2为0.4小时。Animal Model:Female CD-1 mice
Dosage:5 mg/kg
Administration:Oral administration (Pharmacokinetic study)
Result:Moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34), and showed remarkably low plasma protein binding in mice (40%).
产品资料
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