产品
编 号：F237279
分子式：C8Cl4N2
分子量：265.91
分子式：C8Cl4N2
分子量：265.91
产品类型
规格
价格
是否有货
250mg
280
In-stock
500mg
440
In-stock
结构图
CAS No: 1897-45-6
产品详情
生物活性：
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity.
体内研究：
Chlorothalonil (400-600 mg/kg; 口服; 一天一次连续18天) 在妊娠 ICR 小鼠中会产生毒性和胎儿毒性。Chlorothalonil (0.1-10 mg/kg; 口服; 一天一次连续 5 周) 在 ICR 小鼠体内会降低精子活力，抑制精子发生。Animal Model:ICR mouse model of pregnancy
Dosage:100 mg/kg, 400 mg/ kg, 600 mg/kg
Administration:Oral gavage (p.o.); Once daily for 18 days
Result:Reduced weight gain in pregnant mice at doses of 400 mg/kg and 600 mg/kg throughout pregnancy by 36% and 48%, respectively.Significantly increased embryo mortality at doses of 400 mg/kg and 600 mg/kg.Significantly reduced number of live births (28%).Reduced mean fetal weight (22% to 39%) at doses of 400 and 600 mg/kg.
Animal Model:ICR male mice model
Dosage:0.1mg/kg, 1 mg/ kg, 10 mg/kg
Administration:Oral gavage (p.o.); Once daily for 5 weeks
Result:Decreased sperm motility in ICR mice.At doses of 1 mg/kg and 10 mg/kg, decreased the protein factors A-myb, GDNF and DDX4, and finally interrupted the spermatogenesis process.Decreased the sperm marker Acrosin and PNA in a dose-dependent manner at doses of 1 mg/kg and 10 mg/kg.At doses of 1 mg/kg and 10 mg/kg, Significantly reduced the number of estrogen receptor Alpha (ERα) positive stromal cells in mouse testis.Decreased AKT levels in the testis, but did not change p-AKT levels.Disrupted the methylation of histones and DNA.
体外研究：
Chlorothalonil (10mg/kg soil) 能抑制土壤中磷酸酶和脱氢酶活性的活性，降低土壤中微生物的数量。Chlorothalonil (0.6-4.8 μg/mL; 4 天) 在 Caco-2 细胞中通过激活丝裂原活化蛋白激酶 (MAPK) 通路来诱导肠上皮屏障 (IEB) 功能障碍。Chlorothalonil (0.1-10 μM; 4 小时和 24 小时) 以浓度和时间依赖方式降低了猪精子活力，增加了精子的凋亡。
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity.
体内研究：
Chlorothalonil (400-600 mg/kg; 口服; 一天一次连续18天) 在妊娠 ICR 小鼠中会产生毒性和胎儿毒性。Chlorothalonil (0.1-10 mg/kg; 口服; 一天一次连续 5 周) 在 ICR 小鼠体内会降低精子活力，抑制精子发生。Animal Model:ICR mouse model of pregnancy
Dosage:100 mg/kg, 400 mg/ kg, 600 mg/kg
Administration:Oral gavage (p.o.); Once daily for 18 days
Result:Reduced weight gain in pregnant mice at doses of 400 mg/kg and 600 mg/kg throughout pregnancy by 36% and 48%, respectively.Significantly increased embryo mortality at doses of 400 mg/kg and 600 mg/kg.Significantly reduced number of live births (28%).Reduced mean fetal weight (22% to 39%) at doses of 400 and 600 mg/kg.
Animal Model:ICR male mice model
Dosage:0.1mg/kg, 1 mg/ kg, 10 mg/kg
Administration:Oral gavage (p.o.); Once daily for 5 weeks
Result:Decreased sperm motility in ICR mice.At doses of 1 mg/kg and 10 mg/kg, decreased the protein factors A-myb, GDNF and DDX4, and finally interrupted the spermatogenesis process.Decreased the sperm marker Acrosin and PNA in a dose-dependent manner at doses of 1 mg/kg and 10 mg/kg.At doses of 1 mg/kg and 10 mg/kg, Significantly reduced the number of estrogen receptor Alpha (ERα) positive stromal cells in mouse testis.Decreased AKT levels in the testis, but did not change p-AKT levels.Disrupted the methylation of histones and DNA.
体外研究：
Chlorothalonil (10mg/kg soil) 能抑制土壤中磷酸酶和脱氢酶活性的活性，降低土壤中微生物的数量。Chlorothalonil (0.6-4.8 μg/mL; 4 天) 在 Caco-2 细胞中通过激活丝裂原活化蛋白激酶 (MAPK) 通路来诱导肠上皮屏障 (IEB) 功能障碍。Chlorothalonil (0.1-10 μM; 4 小时和 24 小时) 以浓度和时间依赖方式降低了猪精子活力，增加了精子的凋亡。
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