产品
编 号：F237240
分子式：C16H14O5
分子量：286.28
分子式：C16H14O5
分子量：286.28
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CAS No: 189689-32-5
产品详情
生物活性：
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
体外研究：
6,4'-Dihydroxy-7-methoxyflavanone（3-30 μM；巨噬细胞）以剂量依赖性方式抑制破骨细胞生成和 TRAP 活性。6,4'-Dihydroxy-7-methoxyflavanone（0-30 μM；48 小时）会破坏成熟破骨细胞的肌动蛋白环形成。6,4'-Dihydroxy-7-methoxyflavanone（0-30 μM；1 小时；巨噬细胞）通过抑制作用抑制 RANKL 诱导的活化 T 细胞核因子、细胞质、钙调神经磷酸酶依赖性 1 (NFATc1) 和 c-Fos 的表达丝裂原激活蛋白激酶 (MAPK) 通路。
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
体外研究：
6,4'-Dihydroxy-7-methoxyflavanone（3-30 μM；巨噬细胞）以剂量依赖性方式抑制破骨细胞生成和 TRAP 活性。6,4'-Dihydroxy-7-methoxyflavanone（0-30 μM；48 小时）会破坏成熟破骨细胞的肌动蛋白环形成。6,4'-Dihydroxy-7-methoxyflavanone（0-30 μM；1 小时；巨噬细胞）通过抑制作用抑制 RANKL 诱导的活化 T 细胞核因子、细胞质、钙调神经磷酸酶依赖性 1 (NFATc1) 和 c-Fos 的表达丝裂原激活蛋白激酶 (MAPK) 通路。
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