产品
编 号：F237114
分子式：C16H14O4
分子量：270.28
分子式：C16H14O4
分子量：270.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 18956-16-6
产品详情
生物活性：
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.
体内研究：
Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice.Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
体外研究：
Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth.Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein.Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation.Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells.
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.
体内研究：
Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice.Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
体外研究：
Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth.Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein.Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation.Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备