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编 号:F236905
分子式:C27H28F2N4O3
分子量:494.53
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

体内研究:
Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation.Animal Model:Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW.
Dosage:15 mg/kg/day.
Administration:Oral gavage daily for 8 days.
Result:Inhibited ankle swelling in the rat SCW model.
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