产品
编 号：F236742
分子式：C26H26F3N5O2
分子量：497.51
分子式：C26H26F3N5O2
分子量：497.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
询价
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10mg
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50mg
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结构图
CAS No: 1892576-58-7
产品详情
生物活性：
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.
体内研究：
PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice.Animal Model:8?10 week old female Balb/c mice
Dosage:10, 30, and 100 mg/kg
Administration:P.O. daily over 5 days
Result:Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg.
体外研究：
PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM.
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.
体内研究：
PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice.Animal Model:8?10 week old female Balb/c mice
Dosage:10, 30, and 100 mg/kg
Administration:P.O. daily over 5 days
Result:Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg.
体外研究：
PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM.
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