产品
编 号：F236273
分子式：C10H14N2O
分子量：178.23
分子式：C10H14N2O
分子量：178.23
产品类型
规格
价格
是否有货
结构图
CAS No: 188895-96-7
产品详情
生物活性：
Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.
体内研究：
Epiboxidine (20 μg/kg; ip; once) treatment shows marked analgetic activity in mice.Epiboxidine (50 and 100 mg/kg; intraperitoneal injected; once) causes marked antinociception as measured in the hot-plate assay.Epiboxidine inhibits [3H]nicotine binding in rat cerebral cortical membranes, with a Ki of 0.6 nM.Animal Model:Adult male NIH Swiss strain mice (25-30 g)
Dosage:50 and 100 mg/kg
Administration:I.p.; once
Result:Caused a dose-related Straub tail, hypomotility, hypoventilation and piloerection.
体外研究：
Epiboxidine has affinity and functional at central neuronal α4β2 receptors, with Kis of 0.46 and 1.2 in rat and humen.Epiboxidine has activity at ganglionic-type α3β4*-nicotinic receptors of PC12 cells, with a Ki of 19.Epiboxidine is much less toxic than Epibatidine.Epiboxidine stimulates sodium-22 influx in PC12 and TE671 cells, with EC50s of 0.18 and 2.6 μM.
Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.
体内研究：
Epiboxidine (20 μg/kg; ip; once) treatment shows marked analgetic activity in mice.Epiboxidine (50 and 100 mg/kg; intraperitoneal injected; once) causes marked antinociception as measured in the hot-plate assay.Epiboxidine inhibits [3H]nicotine binding in rat cerebral cortical membranes, with a Ki of 0.6 nM.Animal Model:Adult male NIH Swiss strain mice (25-30 g)
Dosage:50 and 100 mg/kg
Administration:I.p.; once
Result:Caused a dose-related Straub tail, hypomotility, hypoventilation and piloerection.
体外研究：
Epiboxidine has affinity and functional at central neuronal α4β2 receptors, with Kis of 0.46 and 1.2 in rat and humen.Epiboxidine has activity at ganglionic-type α3β4*-nicotinic receptors of PC12 cells, with a Ki of 19.Epiboxidine is much less toxic than Epibatidine.Epiboxidine stimulates sodium-22 influx in PC12 and TE671 cells, with EC50s of 0.18 and 2.6 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备