产品
编 号：F236180
分子式：C28H27NO2S
分子量：441.58
分子式：C28H27NO2S
分子量：441.58
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CAS No: 188844-52-2
产品详情
生物活性：
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.
体内研究：
HX630（5 mg/kg，腹腔注射，每周 3 次，持续 3 周）在感染了AtT20 细胞的 BALB/c-nu 小鼠模型中，可以减少肿瘤的生长。Animal Model:Female BALB/c-nu mice (nu/nu)?with AtT20 cells
Dosage:5 mg/kg
Administration:i.p., 3 times a week for 3 weeks
Result:Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
体外研究：
HX630 (0.1-10 μM, 96 h) 可以剂量依赖性的抑制细胞增殖诱导 AtT20 细胞凋亡。
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.
体内研究：
HX630（5 mg/kg，腹腔注射，每周 3 次，持续 3 周）在感染了AtT20 细胞的 BALB/c-nu 小鼠模型中，可以减少肿瘤的生长。Animal Model:Female BALB/c-nu mice (nu/nu)?with AtT20 cells
Dosage:5 mg/kg
Administration:i.p., 3 times a week for 3 weeks
Result:Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
体外研究：
HX630 (0.1-10 μM, 96 h) 可以剂量依赖性的抑制细胞增殖诱导 AtT20 细胞凋亡。
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