产品
编 号：F235988
分子式：C28H29ClN6O5
分子量：565.02
分子式：C28H29ClN6O5
分子量：565.02
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1887161-80-9
产品详情
生物活性：
RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo.
体内研究：
RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model.RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng?h/mL at 1 mg/kg, po).RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.Animal Model:Mice.
Dosage:30 mg/kg.
Administration:Orally twice: at 30 min before and 8 h after IL-23 administration.
Result:Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.
RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo.
体内研究：
RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model.RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng?h/mL at 1 mg/kg, po).RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.Animal Model:Mice.
Dosage:30 mg/kg.
Administration:Orally twice: at 30 min before and 8 h after IL-23 administration.
Result:Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.
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