产品
编 号：F235825
分子式：C26H33ClN2O2
分子量：441.01
分子式：C26H33ClN2O2
分子量：441.01
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规格
价格
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结构图
CAS No: 188589-66-4
产品详情
生物活性：
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).
体内研究：
Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight.Animal Model:ORX rats
Dosage:10 mg/kg
Administration:I.s.; 7 days
Result:Effect of Cl-4AS-1 on prostate and seminal vesicle growth.
体外研究：
Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells.Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%.
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).
体内研究：
Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight.Animal Model:ORX rats
Dosage:10 mg/kg
Administration:I.s.; 7 days
Result:Effect of Cl-4AS-1 on prostate and seminal vesicle growth.
体外研究：
Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells.Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%.
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