产品
编 号：F235666
分子式：C21H21BrN4O5
分子量：489.32
分子式：C21H21BrN4O5
分子量：489.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 1884220-36-3
产品详情
生物活性：
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2.
体内研究：
SBI-0206965 (50?mg/kg; i.p.; once every 3 days for 37 days) inhibites tumour growth and induces apoptosis in A498 xenograft tumours.Animal Model:Six-week-old male BALB/c nude mice (A498 xenograft tumours)
Dosage:50?mg/kg
Administration:Intraperitoneal injection; once every three days for 37 days
Result:Significantly suppressed tumour growth.
体外研究：
SBI-0206965 (5-20 μM; 24 hours) induces apoptosis of A498 and ACHN cells during starvation.SBI-0206965 (5-20 μM; 24 hours) attenuates the phosphorylation of Ser108 of the AMPK β1 subunit and increases the levels of cleaved Caspase 8 and PARP, markers of apoptosis.
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2.
体内研究：
SBI-0206965 (50?mg/kg; i.p.; once every 3 days for 37 days) inhibites tumour growth and induces apoptosis in A498 xenograft tumours.Animal Model:Six-week-old male BALB/c nude mice (A498 xenograft tumours)
Dosage:50?mg/kg
Administration:Intraperitoneal injection; once every three days for 37 days
Result:Significantly suppressed tumour growth.
体外研究：
SBI-0206965 (5-20 μM; 24 hours) induces apoptosis of A498 and ACHN cells during starvation.SBI-0206965 (5-20 μM; 24 hours) attenuates the phosphorylation of Ser108 of the AMPK β1 subunit and increases the levels of cleaved Caspase 8 and PARP, markers of apoptosis.
产品资料
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