产品
编 号：F235585
分子式：C17H15Cl3N4
分子量：381.69
分子式：C17H15Cl3N4
分子量：381.69
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1883548-96-6
产品详情
生物活性：
Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties.
体内研究：
Liarozole dihydrochloride (5-20 mg/kg; p.o.) reverses the vaginal keratosis caused by estrogen stimulation.Liarozole dihydrochloride (40 mg/kg; p.o.) reduces tumor burden substantially.Animal Model:Ovariectomized rats
Dosage:5~20 mg/kg
Administration:P.o.
Result:Reversed the vaginal keratosis caused by estrogen stimulation.
Animal Model:SCID mice
Dosage:40 mg/kg
Administration:P.o.
Result:Inhibited tumor growth and survival.
体外研究：
Liarozole dihydrochloride (0.01~10 μM; 9 days; MCF-7 cells) inhibits cells proliferation.Liarozole dihydrochloride (1 μM; 4 days; mesenchymal cells) completely inhibits chondrogenesis.
Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties.
体内研究：
Liarozole dihydrochloride (5-20 mg/kg; p.o.) reverses the vaginal keratosis caused by estrogen stimulation.Liarozole dihydrochloride (40 mg/kg; p.o.) reduces tumor burden substantially.Animal Model:Ovariectomized rats
Dosage:5~20 mg/kg
Administration:P.o.
Result:Reversed the vaginal keratosis caused by estrogen stimulation.
Animal Model:SCID mice
Dosage:40 mg/kg
Administration:P.o.
Result:Inhibited tumor growth and survival.
体外研究：
Liarozole dihydrochloride (0.01~10 μM; 9 days; MCF-7 cells) inhibits cells proliferation.Liarozole dihydrochloride (1 μM; 4 days; mesenchymal cells) completely inhibits chondrogenesis.
产品资料
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