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编 号：F235527
分子式：C25H33NO2
分子量：379.54
分子式：C25H33NO2
分子量：379.54
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CAS No: 1883345-06-9
产品详情
生物活性：
Udifitimod (BMS-986166) is a potent, selective and orally active S1P1R modulator. Udifitimod has the potential for the research of autoimmune diseases.
体内研究：
Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 21 days) 在自身免疫性脑脊髓炎模型中显示出抗炎活性。Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 50 days) 降低了胶原诱导性关节炎 (CIA) 模型的临床评分和足爪组织学评分。Animal Model:6-8 weeks, C57BL/6 female mice (autoimmune encephalomyelitis model (EAE))
Dosage:0.1, 0.5 mg/kg
Administration:P.o.; once daily for 21 days
Result:Showed a dose-dependent reduction in clinical scores for inflammation.
Animal Model:DBA/1 mice (collagen-induced arthritis (CIA) model)
Dosage:0.1, 0.5 mg/kg
Administration:P.o.; once daily for 50 days
Result:Dose dependently reduced both the clinical score as well as the paw histology score following the dosing regimens.
Udifitimod (BMS-986166) is a potent, selective and orally active S1P1R modulator. Udifitimod has the potential for the research of autoimmune diseases.
体内研究：
Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 21 days) 在自身免疫性脑脊髓炎模型中显示出抗炎活性。Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 50 days) 降低了胶原诱导性关节炎 (CIA) 模型的临床评分和足爪组织学评分。Animal Model:6-8 weeks, C57BL/6 female mice (autoimmune encephalomyelitis model (EAE))
Dosage:0.1, 0.5 mg/kg
Administration:P.o.; once daily for 21 days
Result:Showed a dose-dependent reduction in clinical scores for inflammation.
Animal Model:DBA/1 mice (collagen-induced arthritis (CIA) model)
Dosage:0.1, 0.5 mg/kg
Administration:P.o.; once daily for 50 days
Result:Dose dependently reduced both the clinical score as well as the paw histology score following the dosing regimens.
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