产品
编 号：F235233
分子式：C14H18N6O.1/2H2O4S
分子量：335.38
分子式：C14H18N6O.1/2H2O4S
分子量：335.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
400
In-stock
50mg
912
In-stock
结构图
CAS No: 188062-50-2
产品详情
生物活性：
Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
体内研究：
Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation.Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)
Dosage:2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
体外研究：
Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines.Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion.Abacavir sulfate induces fat apoptosis.
Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity.
体内研究：
Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation.Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)
Dosage:2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
体外研究：
Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines.Abacavir (15 and 150 μM, 18 h) sulfate significantly reduces cell migration and inhibits cell invasion.Abacavir sulfate induces fat apoptosis.
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